In this paper we have further explored a highly effective means of nerve repair known as axonal fusion. We reveal how the protein (EFF-1) that fuses axon segments together after they have been separated by injury is regulated. This is essential information for our understanding of axonal fusion and provides important information for harnessing this type of repair in clinical settings.
The details of the paper are as follows:
RAB-5 regulates regenerative axonal fusion by controlling EFF-1 endocytosis
Casey Linton, Brent Neumann, Rosina Giordano-Santini, Massimo A Hilliard
This is the first time we have used a pre-print server. The manuscript is simultaneously under submission at a more traditional journal.