Neumann Lab
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    • Axonal Regeneration
    • Charcot-Marie-Tooth Disease and Mfn2
    • Axonal Degeneration
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    • Dr Brent Neumann
    • Jean-Sebastien Teoh
    • Tarika Vijayaraghavan
    • Samiksha Dhananjay
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2022
Dhananjay S, Chandhok G*, Neumann B* (2022). Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. ​Micropublication: biology. 10.17912/micropub.biology.000674. Journal link.
Cutrupi AN, Narayanan RK, Perez-Siles G, Grosz BR, Lai K, Boyling A, Ellis M, Lin RCY, Neumann B, Mao D, Uesugi M, Nicholson GA, Vucic S, Saporta MA, Kennerson ML (2022). Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. ​Brain, awac424, https://doi.org/10.1093/brain/awac424. Journal link.
cutrupi_2022_brain.pdf
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Teoh JS*, Dhananjay S*, Neumann B (2022). Mutation of the H12-helix of α-tubulin/MEC-12 disrupts the localization of neuronal mitochondria. ​Micropublication: biology. https://doi.org/10.17912/micropub.biology.000659. Journal link.
teoh_2022_micropub.pdf
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Cobham AE, Neumann B, Mirth CK (2020). Maintaining robust size across environmental conditions through plastic growth dynamics. Open Biology.12220037220037. http:doi.org/10.1098/rsob.220037. Journal link.
cobham_2022_openbiol.pdf
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Teoh JS, Vasudevan A, Wang W, Dhananjay S, Chandhok G, Pocock R, Koushika SP, Neumann B (2022). Synaptic branch stability is mediated by non‑enzymatic functions of MEC‑17/αTAT1 and ATAT‑2. ​Scientific Reports 12, 14003. https://doi.org/10.1038/s41598-022-18333-2. Journal link.
teoh_2022_scirep.pdf
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Vijayaraghavan T, Dhananjay S, Neumann B (2022). DYN-1/dynamin regulates microtubule dynamics after axon injury. ​Micropublication: biology. https://10.17912/micropub.biology.000549. Journal link.
vijayaraghavan_2022_micropub.pdf
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Narayanan RK, Brewer MH, Perez-Siles G, Ellis M, Ly C, Burgess A, Neumann B, Nicholson GA, Vucic S, Kennerson ML (2022). Charcot-Marie-Tooth disease causing mutation (p.R158H) in pyruvate dehydrogenase kinase 3 (PDK3) affects synaptic transmission, ATP production and causes neurodegeneration in a CMTX6 Caenorhabditis elegans model. Human Molecular Genetics 31(1): 133-145. Journal link.
2020
Cobham AE, Neumann B, Mirth CK (2020). Maintaining robust size across environmental conditions is achieved through plastic growth dynamics in the central nervous system of Drosophila melanogaster. bioRxiv 277046; doi: https://doi.org/10.1101/2020.09.01.277046.
cobham_2020_biorxiv.pdf
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Soh MS, Cheng X, Vijayaraghavan T, Vernon A, Liu J, Neumann B (2020). Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans. PLoS ONE 15(4): e0231600. Journal link. bioRxiv version. Brief summary.
soh_2020_plosone.pdf
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2019
Neumann B and Hilliard MA (2019). Axonal repair by fusion: pitfalls, consequences and solutions. The FASEB Journal 33: 13071-13074. Journal link. Brief summary.
neumann_2019_progneurobiol.pdf
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Teoh JS*, Soh MS*, Byrne JJ*, Neumann B (2019). Quantitative approaches for studying cellular structures and organelle morphology in C. elegans​. Journal of Visualized Experiments (149) e59978. See the video here. Journal link. Brief summary.
Byrne JJ, Soh MS*, Chandhok G*, Vijayaraghavan T, Teoh JS, Crawford S, Cobham AE, Yapa NMB, Mirth CK, Neumann B (2019). Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans. Cellular and Molecular Life Sciences 76:1967–1985. Journal link. Brief summary. Cover image.
byrne_2019_cmls.pdf
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Linton C, Riyadh MA, Ho XY, Neumann B, Giordano-Santini R, Hilliard MA (2019). Disruption of RAB-5 increases EFF-1 fusogen availability at the cell surface and promotes the regenerative axonal fusion capacity of the neuron. Journal of Neuroscience 39 (15) 2823-2836. Journal link. Cover image. bioRxiv version. Media release.
linton_2019_jneurosci.pdf
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Microscopic worms could provide key to repairing injured nerves
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Neumann B*, Linton C, Giordano-Santini R, Hilliard MA (2019). Axonal fusion: an alternative and efficient mechanism of nerve repair. Progress in Neurobiology - Review Feb; 173: 88-101. Journal link.
*First and corresponding author.
2019_neumann_progneurobiol.pdf
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2018
Teoh JS*, Wong MYY*, Vijayaraghavan T*, and Neumann B (2018). Bridging the gap: axonal fusion drives rapid functional recovery of the nervous system. Neural Regeneration Research - Invited Review 13(4): 591-594. Journal link.
teoh_2018_nrr.pdf
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Chandhok S, Lazarou M, and Neumann B (2018). Structure, Function, and Regulation of Mitofusin-2 in Health and Disease. Biological Reviews - Review 93(2): 933-949. Journal link.
chandhok_2018_biolrev.pdf
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2017
Abay ZC, Wong MYY, and Neumann B (2017). daf-2 regeneration of mechanosensory neurons: integration. ​Micropublication: biology https://doi.org/10.17912/W2NW9C. Journal link.
Abay ZC, Wong MYY, and Neumann B (2017). daf-2 modulates regeneration of mechanosensory neurons II. Micropublication: biology https://doi.org/10.17912/W2SM1T. Journal link.
Abay ZC, Wong MYY, and Neumann B (2017). daf-2 modulates regeneration of mechanosensory neurons I. Micropublication: biology https://doi.org/10.17912/W2XD3R. Journal link.
abay_2017_micropub_I.pdf
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abay_2017_micropub_II.pdf
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abay_2017_micropub_III.pdf
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Abay ZC, Wong MYY, Teoh JS, Vijayaraghavan T, Hilliard MA, and Neumann B (2017). Phosphatidylserine ‘save-me’ signals drive functional recovery of severed axons in Caenorhabditis elegans. Proceedings of the National Academy of Sciences 114(47): E10196–E10205. Journal link. Media release. Brief summary. Champagne celebrations!
abay_2017_pnas.pdf
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Scientists find way to control nerve injury repair.pdf
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Ritchie FK*, Knable R*, Chaplin J*, Gursanscky R, Gallegos M, Neumann B, and Hilliard MA (2017). The heterochronic gene lin-14 controls axonal degeneration in C. elegans neurons. Cell Reports 20(12): 2955-2965. Journal link. 
​
Media release. Brief summary. Short commentary by Cell Reports.
ritchie_2017_cell_rep.pdf
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New nerve degeneration molecule identified
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Juozaityte V, Morera DP, Podolska A, Nørgaard S, Neumann B, and Pocock R (2017). The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety. Proceedings of the National Academy of Sciences 114(9):E1651-E1658. Journal link. Media release.
juozaityte_2017_pnas.pdf
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Worm gene could be key to developing obesity treatment.pdf
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2016
Nichols ALA, Meelkop E, Linton C, Giordano-Santini R, Sullivan RK, Donato A, Nolan C, Hall DH, Xue D, Neumann B*, and Hilliard MA* (2016).  The apoptotic engulfment machinery regulates axonal degeneration in C. elegans neurons. Cell Reports 14(7): 1673–1683. *Corresponding authors. PubMed link. Media release.
nichols_2016_cell_rep.pdf
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Tiny worm opens big discovery on nerve degeneration
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​Neumann B*, Coakley S, Giordano-Santini R, Abay ZC, Linton C, Seung Lee E, Nakagawa A, Xue D, and Hilliard MA (2016). Molecular characterisation of axonal fusion, a highly efficient means of nervous system repair. Frontiers in Cellular Neuroscience - Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00073. *Corresponding author. Journal Link.
Chandhok S*, and Soh MS* (2016). Presynaptic deficits at neuromuscular junctions: a specific cause and potential target of axonal neuropathy in type 2 Charcot-Marie-Tooth disease. The Journal of Neuroscience - Review 3;36(31):8067-9. *Equal contribution. PubMed link. 
chandhok_2016_j_neurosci.pdf
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2015
Neumann B, Coakley S, Giordano-Santini R, Linton C, Lee ES, Nakagawa A, Xue D, and Hilliard MA (2015).  EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway. Nature 517(7533): 219-222.  PubMed link.  
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Cover image
.  Faculty of 1000 recommendation.
neumann_2015_nature.pdf
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Tiny worm could lead to treatments for nerve injury
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2014
Neumann B, and Hilliard MA (2014). Loss of MEC-17 leads to microtubule instability and axonal degeneration. Cell Reports 6(1): 93-103.  PubMed link.    
neumann_2014_cell_rep.pdf
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Research into axon degeneration hits a nerve
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2013
Kirszenblat L, Neumann B, Coakley S, and Hilliard MA (2013). A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons. Molecular Biology of the Cell 24(3): 285-296.  PubMed link.  Cover image.
kirszenblat_2013_mol_biol_cell.pdf
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2011
Neumann B, Nguyen KC, Hall DH, Ben-Yakar A, and Hilliard MA (2011). Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons. Developmental Dynamics 240(6): 1365-1372.  PubMed link.  
​Cover image.  Editors' Choice highlight in Science.  Highlight in Developmental Dynamics.
neumann_2011_dev_dyn.pdf
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QBI researchers probe nervous system repair
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2008
Neumann B, Zhao L, Murphy K, and Gonda TJ (2008). Subcellular localization of the Schlafen protein family. Biochemical and Biophysical Research Communications 370(1): 62-66.  PubMed link.
neumann_2008_biochem_biophys_res_commun.pdf
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Zhao L, Neumann B, Murphy K, Silke J, and Gonda TJ (2008). Lack of reproducible growth inhibition by Schlafen1 and Schlafen2 in vitro. Blood Cells Molecules and Disease 41(2): 188-193.  PubMed link. 
zhao_2008_blood_cells_mol_dis.pdf
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Our Research

Axonal Regeneration
Charcot-Marie-Tooth Disease & Mfn2
Axonal Degeneration

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