Our paper has now been officially accepted in Cell Reports!!
Brent has co-authored a paper that has been accepted in principle for publication in Cell Reports!
Our results define how the lin-14 heterochronic gene (one responsible for controlling the timing of developmental processes) controls axonal degeneration in C. elegans. We found that interactions between an axon and it's surrounding environment is critical for preserving axonal structure throughout life. Interestingly, the function of the LIN-14 transcription factor is only required very early during development in order to preserve the function of the axon over the lifetime of the worms.
This research provides fundamental insights into the cellular mechanisms needed to keep neuronal architecture, and therefore neuronal function, intact. Furthermore, this has implications for neurodegenerative diseases, including Alzheimer's, Parkinson's, motor neurone, and Charcot-Marie-Tooth diseases, in which axonal degeneration is a common hallmark.
More information can be found on our publications page.