Brent's review on axonal fusion has been accepted for publication!!
The review titled "Axonal fusion: an alternative and efficient mechanism of nerve repair", has been accepted for publication in Progress in Neurobiology.
The manuscript will now proceed to the copy editing process, and hopefully be published soon.
Today we welcome Arwen Vernon to the Neumann lab.
Arwen will begin a 5 week Summer Research Scholarship position with us, before starting an Honours research project in 2019.
Our funding from the Charcot-Marie-Tooth Disease Association (CMTAA) was made possible by the local fundraising efforts in the town of Deniliquin.
The local community's fundraising led to a donation to the CMTAA, which was then used to support our research searching for the first therapeutic for Charcot-Marie-Tooth disease.
This has led to significant local media interest in the town of Deniliquin, which more than a dozen news sites featuring the story. These include the Deniliquin Pastoral Times, Shepparton News, and McIvor Times.
We are very appreciative of the Deniliquin community!
We have a review article under review at Progress in Neurobiology!
In collaboration with members of Massimo Hilliard's lab, we have written a review on regenerative axonal fusion.
This article covers covers our current knowledge around this highly efficient mechanism of nervous system repair. Our previous work on this in C. elegans, observations in other invertebrate species, and the use of similar paradigms in mammals (including one study in humans) is all covered in our comprehensive review.
Hoping for a positive response from the reviewers!
This week we have a visitor in the lab - Dr Ramesh Narayanan from Marina Kennerson's lab at the ANZAC Research Institute in Sydney.
Brent is attending the Rare Disease: Australian Functional Genomics Conference at the Bio21 Institute, The University of Melbourne.
The goal of the conference is to facilitate the clinical interpretation of genetic variants and how researchers using model organisms can help with the identification of disease causing genetic mutations.
Brent is presenting some of the Neumann labs research on CMT in a poster entitled: Understanding the role of Mitofusin-2 in Charcot-Marie-Tooth disease.
The poster session was combined with drinks and canapes adjacent the dinosaur exhibition at Melbourne Museum - an amazing and unique location for the event (see pic below)!
Information on the conference can be found here.
Brent was invited to speak at the Department of Biochemistry and Molecular Biology Innovation Forum at the University of Melbourne.
The talk was titled "Fuse it or Lose it: Highly efficient repair of the nervous system through axonal fusion", and focused on our research of nervous system repair, as well as touching on our other research areas and the advantages of the C. elegans model system.
Our grant application to the Charcot-Marie-Tooth Association Australia (CMTAA) has been successful!!
CMTAA will provide us with $11,250 to support our research aimed at identifying therapeutics for combatting CMT disease.
To find out more about the wonderful work that CMTAA does for CMT patients, see here.
The highly prestigious Neumann Lab trophy is awarded to a member of the lab who has achieved great success or for any other reason we deem appropriate!
The inaugural recipient was Valerie for getting strain number 100 - a wonderfully random achievement!
Current holder of the Top Achievement Award:
Simran: What the HEK!
Awarded for successfully using a CRISPR/Cas9 approach to generate a genetic knockout that is critical for our research.
10. Simran: What the HEK! - culturing mammalian cells (HEK293T's) for the first time in the Neumann lab
9. Tarika: CRISPR Queen - successfully getting a vital CRISPR mutant
8. Ming: Drug Tester - completing a pilot drug screen to identify effective therapeutics for Charcot-Marie-Tooth disease
7. Ming: Magnificent Muscles - taking a truly beautiful image of the C. elegans body wall muscles (now on our CMT research page - see here)
6. Michelle: Confirmed! - successfully completing her 12 month requirements as a PhD candidate
5. Tarika: Money Bags - being awarded three seperate scholarships on a single day
4. Michelle: WGS Success - successful sequencing and mapping various mutants isolated from genetic screening
3. Grace: First lab thesis - the first thesis completed in the Neumann Lab
2. Joe: CRISPR King - successfully getting a CRISPR mutant for the first time in the lab
1. Valerie: Strain 100 - generating strain #100 in the Neumann Lab