Welcome Ramesh!
This week we have a visitor in the lab - Dr Ramesh Narayanan from Marina Kennerson's lab at the ANZAC Research Institute in Sydney.
Welcome Ramesh!
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Brent is attending the Rare Disease: Australian Functional Genomics Conference at the Bio21 Institute, The University of Melbourne.
The goal of the conference is to facilitate the clinical interpretation of genetic variants and how researchers using model organisms can help with the identification of disease causing genetic mutations. Brent is presenting some of the Neumann labs research on CMT in a poster entitled: Understanding the role of Mitofusin-2 in Charcot-Marie-Tooth disease. The poster session was combined with drinks and canapes adjacent the dinosaur exhibition at Melbourne Museum - an amazing and unique location for the event (see pic below)! Information on the conference can be found here. Brent was invited to speak at the Department of Biochemistry and Molecular Biology Innovation Forum at the University of Melbourne.
The talk was titled "Fuse it or Lose it: Highly efficient repair of the nervous system through axonal fusion", and focused on our research of nervous system repair, as well as touching on our other research areas and the advantages of the C. elegans model system. Our grant application to the Charcot-Marie-Tooth Association Australia (CMTAA) has been successful!!
CMTAA will provide us with $11,250 to support our research aimed at identifying therapeutics for combatting CMT disease. To find out more about the wonderful work that CMTAA does for CMT patients, see here. The first paper from our lab on mitochondrial dynamics is now under review at Cellular and Molecular Life Sciences!!
This work is related to our research into the molecular mechanisms of Charcot-Marie-Tooth disease. We have studied how the loss of the major mitochondrial fusion and fission proteins affects mitochondrial morphology in different tissues, animals behaviour and longevity in C. elegans. Hoping for a positive response from the reviewers.... Brent is attending the 2018 C. elegans Topic Meeting: Neuronal Development, Synaptic Function and Behaviour at the University of Madison, Wisconsin USA.
Conference details can be found here: http://conferences.union.wisc.edu/ceneuro/ And follow all the updates via Twitter @neumannlab and #ceneuro #ceneuro18 Brent was invited as a 'VIP' for the Students of Brain Research (SoBR) Professional Development Dinner held at the Arts Center Melbourne.
This annual dinner aims to foster discussion on the future of brain science. The VIP guests are seated at each table alongside young researchers to help convey their thoughts on careers in science and the future of brain research. More info on the dinner and society can be found here: www.sobrnetwork.org We have published a manuscript in collaboration with Massimo Hilliard's lab online with bioRxiv: https://www.biorxiv.org/content/early/2018/06/18/339150
In this paper we have further explored a highly effective means of nerve repair known as axonal fusion. We reveal how the protein (EFF-1) that fuses axon segments together after they have been separated by injury is regulated. This is essential information for our understanding of axonal fusion and provides important information for harnessing this type of repair in clinical settings. The details of the paper are as follows: RAB-5 regulates regenerative axonal fusion by controlling EFF-1 endocytosis Casey Linton, Brent Neumann, Rosina Giordano-Santini, Massimo A Hilliard This is the first time we have used a pre-print server. The manuscript is simultaneously under submission at a more traditional journal. Today we welcome Clara Luu to the Neumann lab.
Clara is a final year Biomedical Science student joining us for a 4-week Winter Scholarship research project, before starting a 12-week research project as part of the DEV3990 course. Clara will be working with Sebastien and Tarika on a project aiming to understand how the nervous system can be repaired after injury. Welcome Clara!! Brent was invited to speak at the Monash BDI Rising Stars Seminar Series.
His talk is entitled "Title: Fuse it or lose it: highly efficient repair of the nervous system through axonal fusion". Some photos from the presentation were posted to Twitter: https://twitter.com/TarikaVR/status/1004262945616883712 https://twitter.com/sjturn/status/1004243095653777408 https://twitter.com/sjturn/status/1004246934427561984 |
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